Tumor perfusion changes

A single-shot electrotherapy with 0,6 rnA direct current for 60 minutes delivered via two needle electrodes placed subcutaneously on opposite sides of a tumor induced statistically significant tumor growth delay in SA-l and LPB murine fibrosarcoma tumor models, A prolonged vascular occlusion is indicated by the results of staining tumors with a Patent Blue dye in the SA-l tumor model immediately and 24 hours after one hour electrotherapy. The almost complete absence of tumor staining after treatment with electrotherapy in SA-l tumors suggested that the tumor growth retardation could result from this prolonged vascular occlusion. However. statistically highly significant tumor growth delay in LPB tumors was accompanied by only a slight decrease of a tumor staining with Patent Blue. Thus. the observed effect of electrotherapy on both tumor growth retardation and perfusion in the LPB tumor model raises some doubt about the above hypothesis. © 1997 Elsevier Science S.A.